Pseudomonas aeruginosa UCBPP-PA14, PA14_19630 (folE1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0046654 tetrahydrofolate biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PTHR11109
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003934 GTP cyclohydrolase I activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PTHR11109
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Biosynthesis of cofactors, prosthetic groups and carriers Other UCBPP-PA14 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pau01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00790 Folate biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:1.10.286.10 - IPR043134 GTP cyclohydrolase I, N-terminal domain 1 50 1.8E-19
PANTHER PTHR11109 GTP CYCLOHYDROLASE I IPR001474 GTP cyclohydrolase I 3 183 3.9E-85
NCBIfam TIGR00063 JCVI: GTP cyclohydrolase I FolE IPR001474 GTP cyclohydrolase I 6 183 4.8E-77
CDD cd00642 GTP_cyclohydro1 - - 3 184 2.88187E-97
Pfam PF01227 GTP cyclohydrolase I IPR020602 GTP cyclohydrolase I domain 6 182 1.9E-75
Gene3D G3DSA:3.30.1130.10 - IPR043133 GTP cyclohydrolase I, C-terminal/NADPH-dependent 7-cyano-7-deazaguanine reductase 53 185 5.3E-64
FunFam G3DSA:3.30.1130.10:FF:000001 GTP cyclohydrolase 1 - - 53 184 5.2E-61
SUPERFAMILY SSF55620 Tetrahydrobiopterin biosynthesis enzymes-like - - 5 183 8.89E-79
FunFam G3DSA:1.10.286.10:FF:000009 GTP cyclohydrolase 1 - - 1 50 2.4E-30
Hamap MF_00223 GTP cyclohydrolase 1 [folE]. IPR001474 GTP cyclohydrolase I 1 183 39.246246

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.