Pseudomonas aeruginosa UCBPP-PA14, PA14_52800 (acsA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0003987 acetate-CoA ligase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR02188
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016208 AMP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR02188
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0019427 acetyl-CoA biosynthetic process from acetate
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR02188
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Central intermediary metabolism Other UCBPP-PA14 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pau01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00680 Methane metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00010 Glycolysis / Gluconeogenesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01120 Microbial metabolism in diverse environments 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01200 Carbon metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00620 Pyruvate metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00640 Propanoate metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
NCBIfam TIGR02188 JCVI: acetate--CoA ligase IPR011904 Acetate-CoA ligase 21 643 0.0
Pfam PF13193 AMP-binding enzyme C-terminal domain IPR025110 AMP-binding enzyme, C-terminal domain 531 609 7.5E-25
CDD cd05966 ACS - - 23 634 0.0
Pfam PF00501 AMP-binding enzyme IPR000873 AMP-dependent synthetase/ligase domain 83 522 1.9E-93
Hamap MF_01123 Acetyl-coenzyme A synthetase [acs]. IPR011904 Acetate-CoA ligase 2 645 51.996025
Gene3D G3DSA:3.40.50.12780 - IPR042099 ANL, N-terminal domain 3 517 0.0
FunFam G3DSA:3.30.300.30:FF:000004 Acetyl-coenzyme A synthetase - - 518 649 2.8E-65
SUPERFAMILY SSF56801 Acetyl-CoA synthetase-like - - 17 642 0.0
Pfam PF16177 Acetyl-coenzyme A synthetase N-terminus IPR032387 Acetyl-coenzyme A synthetase, N-terminal domain 24 81 2.7E-22
FunFam G3DSA:3.40.50.12780:FF:000001 Acetyl-coenzyme A synthetase - - 5 517 0.0
PANTHER PTHR24095 ACETYL-COENZYME A SYNTHETASE - - 19 646 0.0
Gene3D G3DSA:3.30.300.30 - IPR045851 AMP-binding enzyme, C-terminal domain superfamily 518 651 2.4E-33

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.