Pseudomonas aeruginosa PAO1, PA0059 (osmC)

Cytoplasmic Membrane
Outer Membrane
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
Replicon chromosome
Genomic location 73468 - 73923 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs


RefSeq NP_248749.1
GI 15595257
Affymetrix PA0059_osmC_at
Entrez 878070
GenBank AAG03449.1
INSDC AAG03449.1
NCBI Locus Tag PA0059
protein_id(GenBank) gb|AAG03449.1|AE004445_10|gnl|PseudoCAP|PA0059
UniParc UPI00000C4F0C
UniProtKB Acc Q9I773
UniRef100 UniRef100_Q9I773
UniRef50 UniRef50_P0C0L2
UniRef90 UniRef90_Q9I773


Feature Type CDS
Coding Frame 1
Product Name
osmotically inducible protein OsmC
Product Name Confidence: Class 2
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.35
Kyte-Doolittle Hydrophobicity Value -0.131
Molecular Weight (kDa) 15.6
Isoelectric Point (pI) 6.25

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 1
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 220 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000058 (558 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: PA0059
Search term: osmC

Transposon Insertions in PAO1

Type mini-Tn5 lux transposon insertion site (Non-transcriptional fusion)
Mutant ID UBC: PAO1_lux_100_A5
Genomic Position 73540
Position in ORF 73(456)
Reference 15805499
Type Confirmed ISphoA/hah insertion site
Mutant ID UWGC: 47788
Genomic Position 73540
Position in ORF 73(456)
Reference 14617778
Type Confirmed ISlacZ/hah insertion site
Mutant ID UWGC: 2392
Genomic Position 73741
Position in ORF 274(456)
Reference 14617778

Transposon Insertions in Orthologs

Type MAR2xT7 transposon (exoU background) insertion site
Strain Pseudomonas aeruginosa UCBPP-PA14
Locus Tag PA14_00710
Mutant ID PA14NR: 5655
Genomic Position 71235
Position in ORF 124(456)
Reference 16477005


Osmotic induction of gene osmC expression in Escherichia coli K12.
Gutierrez C, Devedjian JC.
J Mol Biol. 1991 Aug 20;220(4):959-73.
PubMed ID: 1715407
Growth-phase-dependent expression of the osmotically inducible gene osmC of Escherichia coli K-12.
Gordia S, Gutierrez C.
Mol Microbiol. 1996 Feb;19(4):729-36.
PubMed ID: 8820643
Interplay between global regulators of Escherichia coli: effect of RpoS, Lrp and H-NS on transcription of the gene osmC.
Bouvier J, Gordia S, Kampmann G, Lange R, Hengge-Aronis R, Gutierrez C.
Mol Microbiol. 1998 Jun;28(5):971-80.
PubMed ID: 9663683