Pseudomonas aeruginosa PAO1, PA0219

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA0219
Name
Replicon chromosome
Genomic location 247219 - 248709 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1

Cross-References

RefSeq NP_248910.1
GI 15595416
Affymetrix PA0219_at
Entrez 879237
GenBank AAG03608.1
INSDC AAG03608.1
NCBI Locus Tag PA0219
protein_id(GenBank) gb|AAG03608.1|AE004460_1|gnl|PseudoCAP|PA0219
TIGR NTL03PA00220
UniParc UPI00000C4FA2
UniProtKB Acc Q9I6R9
UniProtKB ID Q9I6R9_PSEAE
UniRef100 UniRef100_U8MJD1
UniRef50 UniRef50_C9YAW5
UniRef90 UniRef90_A0A077JPA1

Product

Feature Type CDS
Coding Frame 1
Product Name
probable aldehyde dehydrogenase
Product Name Confidence: Class 3
Evidence for Translation
Charge (pH 7) -10.41
Kyte-Doolittle Hydrophobicity Value -0.036
Molecular Weight (kDa) 53.6
Isoelectric Point (pI) 5.04

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 604 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000218 (409 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0219

Human Homologs

Ensembl 86, assembly GRCh38.p7
aldehyde dehydrogenase 1 family member A2 [Source:HGNC Symbol;Acc:HGNC:15472]
E-value: 2.7e-109
Percent Identity: 44.9

Transposon Insertions in PAO1

Type ISphoA/hah insertion site
Mutant ID UWGC: 35418
Genomic Position 247860
Position in ORF 642(1491)
Reference 14617778
Type ISlacZ/hah insertion site
Mutant ID UWGC: 4287
Genomic Position 247938
Position in ORF 720(1491)
Reference 14617778
Type mini-Tn5 lux transposon insertion site (Transcriptional fusion)
Mutant ID UBC: PAO1_lux_23_C4
Genomic Position 248056
Position in ORF 838(1491)
Reference 15805499

Transposon Insertions in Orthologs

References

Cloning an Escherichia coli gene encoding a protein remarkably similar to mammalian aldehyde dehydrogenases.
Heim R, Strehler EE.
Gene. 1991 Mar 1;99(1):15-23.
PubMed ID: 1840553