Pseudomonas aeruginosa UCBPP-PA14, PA14_18350

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_18350
Name
Replicon chromosome
Genomic location 1574120 - 1576108 (- strand)
Transposon Mutants 2 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq YP_789611.1
GI 116051552
Entrez 4381518
INSDC ABJ12788.1
NCBI Locus Tag PA14_18350
UniParc UPI00003960EC
UniProtKB Acc Q02R25
UniProtKB ID ARNA_PSEAB
UniRef100 UniRef100_Q02R25
UniRef50 UniRef50_O52325
UniRef90 UniRef90_Q9HY63

Product

Feature Type CDS
Coding Frame 1
Product Name
bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase
Synonyms
Evidence for Translation
Charge (pH 7) -3.48
Kyte-Doolittle Hydrophobicity Value -0.258
Molecular Weight (kDa) 74.3
Isoelectric Point (pI) 6.68

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
arnA arnA modifies lipid A with 4-amino-4-deoxy-L-arabinose (Ara4N) which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. arnA is found in E. coli and P. aeruginosa. [PMID:11021929, PMID:15939024] ARO:3002985 protein homolog model Strict 1356.7 99.55 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 651 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002112 (427 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_18350

Human Homologs

Ensembl 110, assembly GRCh38.p14
UDP-glucuronate decarboxylase 1 [Source:HGNC Symbol;Acc:HGNC:17729]
E-value: 5.7e-27
Percent Identity: 27.1
Ensembl 110, assembly GRCh38.p14
UDP-glucuronate decarboxylase 1 [Source:HGNC Symbol;Acc:HGNC:17729]
E-value: 5.7e-27
Percent Identity: 27.1

References

No references are associated with this feature.