Pseudomonas aeruginosa PAO1, PA2585 (uvrC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2585
Name
uvrC
Replicon chromosome
Genomic location 2923961 - 2925787 (- strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_251275.1
GI 15597781
Affymetrix PA2585_uvrC_at
Entrez 880581
GenBank AAG05973.1
INSDC AAG05973.1
NCBI Locus Tag PA2585
protein_id(GenBank) gb|AAG05973.1|AE004687_2|gnl|PseudoCAP|PA2585
TIGR NTL03PA02585
UniParc UPI0000137EE9
UniProtKB Acc Q9I0Q1
UniProtKB ID UVRC_PSEAE
UniRef100 UniRef100_Q9I0Q1
UniRef50 UniRef50_Q9I0Q1
UniRef90 UniRef90_Q9I0Q1

Product

Feature Type CDS
Coding Frame 1
Product Name
excinuclease ABC subunit C
Product Name Confidence: Class 2
Synonyms UvrC
UvrABC endonuclease subunit C
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 8.16
Kyte-Doolittle Hydrophobicity Value -0.265
Molecular Weight (kDa) 67.4
Isoelectric Point (pI) 8.51

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 623 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002961 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2585
Search term: uvrC

Human Homologs

References

Incision of damaged versus nondamaged DNA by the Escherichia coli UvrABC proteins.
Caron PR, Grossman L
Nucleic Acids Res 1988 Aug 25;16(16):7855-65
PubMed ID: 2843804
Global control in Pseudomonas fluorescens mediating antibiotic synthesis and suppression of black root rot of tobacco.
Laville J, Voisard C, Keel C, Maurhofer M, Défago G, Haas D
Proc Natl Acad Sci U S A 1992 Mar 1;89(5):1562-6
PubMed ID: 1311842