Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA2586
|
Name |
gacA
|
Replicon | chromosome |
Genomic location | 2925788 - 2926432 (- strand) |
Transposon Mutants | 1 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 2 transposon mutants in orthologs |
RefSeq | NP_251276.1 |
GI | 15597782 |
Affymetrix | PA2586_gacA_at |
Entrez | 880582 |
GenBank | AAG05974.1 |
INSDC | AAG05974.1 |
NCBI Locus Tag | PA2586 |
protein_id(GenBank) | gb|AAG05974.1|AE004687_3|gnl|PseudoCAP|PA2586 |
TIGR | NTL03PA02586 |
UniParc | UPI000012AFCE |
UniProtKB Acc | Q51373 |
UniProtKB ID | GACA_PSEAE |
UniRef100 | UniRef100_Q51373 |
UniRef50 | UniRef50_Q51373 |
UniRef90 | UniRef90_Q51373 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
response regulator GacA
|
Synonyms | |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -2.19 |
Kyte-Doolittle Hydrophobicity Value | 0.040 |
Molecular Weight (kDa) | 23.6 |
Isoelectric Point (pI) | 6.12 |
Individual Mappings | |
Additional evidence for subcellular localization |
Source 1 | |
Database | PseudoCAP |
Category | GacS/GacA two-component system |
Evidence |
ECO:0000315
mutant phenotype evidence used in manual assertion
|
Host Organism | Bombyx mori |
Notes | gacA mutant strains exhibit reduced killing of silkworm. |
Reference | 15727838 |
Source 2 | |
Database | VFDB |
Category | GacS/GacA two-component system |
Evidence |
|
Host Organism | |
Notes | |
Reference |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 606 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG002960 (533 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA2586
Search term: gacA
Search term: response regulator GacA
|
The global activator GacA of Pseudomonas aeruginosa PAO positively controls the production of the autoinducer N-butyryl-homoserine lactone and the formation of the virulence factors pyocyanin, cyanide, and lipase.
Reimmann C, Beyeler M, Latifi A, Winteler H, Foglino M, Lazdunski A, Haas D
Mol Microbiol 1997 Apr;24(2):309-19
PubMed ID: 9159518
|