Pseudomonas aeruginosa PAO1, PA2592

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2592
Name
Synonym: potF5
Replicon chromosome
Genomic location 2934541 - 2935644 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251282.1
GI 15597788
Affymetrix PA2592_at
Entrez 878741
GenBank AAG05980.1
INSDC AAG05980.1
NCBI Locus Tag PA2592
protein_id(GenBank) gb|AAG05980.1|AE004688_2|gnl|PseudoCAP|PA2592
TIGR NTL03PA02592
UniParc UPI00000C5758
UniProtKB Acc Q9I0P5
UniProtKB ID Q9I0P5_PSEAE
UniRef100 UniRef100_W0YRP0
UniRef50 UniRef50_A6V4I5
UniRef90 UniRef90_A6V4I5

Product

Feature Type CDS
Coding Frame 1
Product Name
probable periplasmic spermidine/putrescine-binding protein
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -0.89
Kyte-Doolittle Hydrophobicity Value -0.218
Molecular Weight (kDa) 40.7
Isoelectric Point (pI) 6.68

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Extracellular Class 1
mass spectrometry evidence used in manual assertion
Periplasmic Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 302 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002956 (376 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2592

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Mep72, a metzincin protease that is preferentially secreted by biofilms of Pseudomonas aeruginosa.
Passmore IJ, Nishikawa K, Lilley KS, Bowden SD, Chung JC, Welch M
J Bacteriol 2015 Feb 15;197(4):762-73
PubMed ID: 25488299