Pseudomonas aeruginosa PAO1, PA2594

Gene Feature Overview

Strain	Pseudomonas aeruginosa PAO1 (Stover et al., 2000) GCF_000006765.1|latest
Locus Tag	PA2594
Name
Replicon	chromosome
Genomic location	2936490 - 2937449 (- strand)
Transposon Mutants	2 transposon mutants in PAO1
Transposon Mutants in orthologs	6 transposon mutants in orthologs
Comment	Structural similarity to 3E4R:alkansulphonate-binding protein SsuA from Xanthomonas axonopodis, root-mean-square deviation:0.6 angstroms). Sequence similarity to 2X26 (98%/42,91%) (no ligand). Final predicted ligand: aliphatic sulphonate (PMID: 31631799)

Cross-References

RefSeq	NP_251284.1
GI	15597790
Affymetrix	PA2594_at
Entrez	882300
GenBank	AAG05982.1
INSDC	AAG05982.1
NCBI Locus Tag	PA2594
protein_id(GenBank)	gb|AAG05982.1|AE004688_4|gnl|PseudoCAP|PA2594
TIGR	NTL03PA02594
UniParc	UPI00000C575A
UniProtKB Acc	Q9I0P3
UniProtKB ID	Q9I0P3_PSEAE
UniRef100	UniRef100_Q9I0P3
UniRef50	UniRef50_C5AZ38
UniRef90	UniRef90_Q9I0P3

Product

Feature Type	CDS
Coding Frame	1
Product Name	putative periplasmic aliphatic sulfonate binding protein Product Name Confidence: Class 3
Synonyms
Evidence for Translation	Detected by MALDI-TOF/TOF (PMID:19333994). Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7)	3.68
Kyte-Doolittle Hydrophobicity Value	-0.146
Molecular Weight (kDa)	34.7
Isoelectric Point (pI)	9.19

Subcellular localization

Individual Mappings	Localization Confidence PMID Unknown Class 3 20472543 Periplasmic Class 1 19333994
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 244 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG002192 (1695 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA2594 Search term: putative periplasmic aliphatic sulfonate binding protein

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen. Lewenza S, Gardy JL, Brinkman FS, Hancock RE Genome Res 2005 Feb;15(2):321-9 PubMed ID: 15687295

Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen. Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM Proteomics 2009 Apr;9(7):1901-15 PubMed ID: 19333994

Uncovering the structure and function of Pseudomonas aeruginosa periplasmic proteins by an in silico approach. Caprari S, Brandi V, Pasquadibisceglie A, Polticelli F J Biomol Struct Dyn 2020 Sep;38(15):4508-4520 PubMed ID: 31631799