Pseudomonas aeruginosa PAO1, PA2620 (clpA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2620
Name
clpA
Replicon chromosome
Genomic location 2962303 - 2964579 (- strand)
Transposon Mutants 5 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_251310.1
GI 15597816
Affymetrix PA2620_clpA_at
Entrez 882326
GenBank AAG06008.1
INSDC AAG06008.1
NCBI Locus Tag PA2620
protein_id(GenBank) gb|AAG06008.1|AE004690_8|gnl|PseudoCAP|PA2620
TIGR NTL03PA02620
UniParc UPI00000C576F
UniProtKB Acc Q9I0L8
UniProtKB ID Q9I0L8_PSEAE
UniRef100 UniRef100_W0YRS1
UniRef50 UniRef50_P0ABI1
UniRef90 UniRef90_Q4K9U8

Product

Feature Type CDS
Coding Frame 1
Product Name
ATP-binding protease component ClpA
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -14.48
Kyte-Doolittle Hydrophobicity Value -0.286
Molecular Weight (kDa) 84.0
Isoelectric Point (pI) 5.89

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 604 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002932 (531 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2620
Search term: clpA

Human Homologs

Ensembl 110, assembly GRCh38.p14
caseinolytic mitochondrial matrix peptidase chaperone subunit B [Source:HGNC Symbol;Acc:HGNC:30664]
E-value: 1.7e-35
Percent Identity: 31.2
Ensembl 110, assembly GRCh38.p14
caseinolytic mitochondrial matrix peptidase chaperone subunit B [Source:HGNC Symbol;Acc:HGNC:30664]
E-value: 1.7e-35
Percent Identity: 31.2
Ensembl 110, assembly GRCh38.p14
caseinolytic mitochondrial matrix peptidase chaperone subunit B [Source:HGNC Symbol;Acc:HGNC:30664]
E-value: 1.7e-35
Percent Identity: 31.2

References

Conservation of the regulatory subunit for the Clp ATP-dependent protease in prokaryotes and eukaryotes.
Gottesman S, Squires C, Pichersky E, Carrington M, Hobbs M, Mattick JS, Dalrymple B, Kuramitsu H, Shiroza T, Foster T
Proc Natl Acad Sci U S A 1990 May;87(9):3513-7
PubMed ID: 2185473
The ATP-dependent Clp protease of Escherichia coli. Sequence of clpA and identification of a Clp-specific substrate.
Gottesman S, Clark WP, Maurizi MR
J Biol Chem 1990 May 15;265(14):7886-93
PubMed ID: 2186030