Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA2623
|
Name |
icd
Synonym: icdA |
Replicon | chromosome |
Genomic location | 2965546 - 2966802 (- strand) |
Transposon Mutants | 3 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 2 transposon mutants in orthologs |
RefSeq | NP_251313.1 |
GI | 15597819 |
Affymetrix | PA2623_icd_at |
Entrez | 882329 |
GenBank | AAG06011.1 |
INSDC | AAG06011.1 |
NCBI Locus Tag | PA2623 |
protein_id(GenBank) | gb|AAG06011.1|AE004691_2|gnl|PseudoCAP|PA2623 |
TIGR | NTL03PA02623 |
UniParc | UPI00000C5771 |
UniProtKB Acc | Q9I0L5 |
UniProtKB ID | Q9I0L5_PSEAE |
UniRef100 | UniRef100_Q02NB5 |
UniRef50 | UniRef50_P08200 |
UniRef90 | UniRef90_Q02NB5 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
isocitrate dehydrogenase
|
Synonyms |
IDH oxalosuccinate decarboxylase |
Evidence for Translation |
Detected by MALDI-TOF/TOF (PMID:19333994).
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected using LC-MS/MS (45.58 kDa, PMID:21751344)
|
Charge (pH 7) | -9.35 |
Kyte-Doolittle Hydrophobicity Value | -0.116 |
Molecular Weight (kDa) | 45.6 |
Isoelectric Point (pI) | 4.85 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
5M2E | OXIDOREDUCTASE | 10/12/16 | Apo structure of Pseudomonas aeruginosa Isocitrate Dehydrogenase, ICD | Pseudomonas aeruginosa | 2.7 | X-RAY DIFFRACTION | 100.0 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 605 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG002929 (494 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA2623
Search term: icd
Search term: isocitrate dehydrogenase
|
Ensembl
110, assembly
GRCh38.p14
|
isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:5384]
E-value:
1.9e-44
Percent Identity:
33.0
|
Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase.
Hurley JH, Thorsness PE, Ramalingam V, Helmers NH, Koshland DE Jr, Stroud RM
Proc Natl Acad Sci U S A 1989 Nov;86(22):8635-9
PubMed ID: 2682654
|
Evolutionary genetics of the isocitrate dehydrogenase gene (icd) in Escherichia coli and Salmonella enterica.
Wang FS, Whittam TS, Selander RK
J Bacteriol 1997 Nov;179(21):6551-9
PubMed ID: 9352899
|
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994
|
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344
|