Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA2634
|
Name |
aceA
Synonym: aceA |
Replicon | chromosome |
Genomic location | 2977756 - 2979351 (+ strand) |
Transposon Mutants | 4 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 2 transposon mutants in orthologs |
Comment | induced by acetate, citronellol and leucine, and repressed by growth on glucose or citrate |
RefSeq | NP_251324.1 |
GI | 15597830 |
Affymetrix | PA2634_at |
Entrez | 882341 |
GenBank | AAG06022.1 |
INSDC | AAG06022.1 |
NCBI Locus Tag | PA2634 |
protein_id(GenBank) | gb|AAG06022.1|AE004692_1|gnl|PseudoCAP|PA2634 |
TIGR | NTL03PA02634 |
UniParc | UPI00000C577B |
UniProtKB Acc | Q9I0K4 |
UniProtKB ID | ACEA_PSEAE |
UniRef100 | UniRef100_Q9I0K4 |
UniRef50 | UniRef50_O50078 |
UniRef90 | UniRef90_Q9I0K4 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
isocitrate lyase AceA
|
Synonyms |
isocitrate lyase |
Evidence for Translation |
Detected by MALDI-TOF/TOF (PMID:19333994).
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -8.85 |
Kyte-Doolittle Hydrophobicity Value | -0.317 |
Molecular Weight (kDa) | 58.9 |
Isoelectric Point (pI) | 5.91 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
6G1O | LYASE | 03/21/18 | Structure of Pseudomonas aeruginosa Isocitrate Lyase, ICL | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 1.882 | X-RAY DIFFRACTION | 100.0 |
Source 1 | |
Database | PseudoCAP |
Category | isocitrate lyase |
Evidence |
ECO:0000315
mutant phenotype evidence used in manual assertion
|
Host Organism | Rattus norvegicus |
Notes | isocitrate lyase mutant is attenuated for virulence in rat agar bead model of chronic lung infection |
Infection model | rat agar bead model of chronic lung infection |
Reference | 18524916 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 273 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG002919 (354 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA2634
Search term: aceA
Search term: isocitrate lyase AceA
|
Identification of the aceA gene encoding isocitrate lyase required for the growth of Pseudomonas aeruginosa on acetate, acyclic terpenes and leucine.
Díaz-Pérez AL, Román-Doval C, Díaz-Pérez C, Cervantes C, Sosa-Aguirre CR, López-Meza JE, Campos-García J
FEMS Microbiol Lett 2007 Apr;269(2):309-16
PubMed ID: 17319879
|
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994
|