Pseudomonas aeruginosa PAO1, PA2927 (plaB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2927
Name
plaB
Synonym: PaPlaB
Replicon chromosome
Genomic location 3281988 - 3283319 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251617.1
GI 15598123
Affymetrix PA2927_at
Entrez 882676
GenBank AAG06315.1
INSDC AAG06315.1
NCBI Locus Tag PA2927
protein_id(GenBank) gb|AAG06315.1|AE004719_1|gnl|PseudoCAP|PA2927
TIGR NTL03PA02927
UniParc UPI00000C588A
UniProtKB Acc Q9HZS0
UniProtKB ID Q9HZS0_PSEAE
UniRef100 UniRef100_Q9HZS0
UniRef50 UniRef50_Q9HZS0
UniRef90 UniRef90_Q9HZS0

Product

Feature Type CDS
Coding Frame 1
Product Name
phospholipase B
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.88
Kyte-Doolittle Hydrophobicity Value -0.234
Molecular Weight (kDa) 49.5
Isoelectric Point (pI) 6.61

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 14 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002649 (297 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2927
Search term: plaB
Search term: phospholipase B

Human Homologs

References

A phospholipase B from Pseudomonas aeruginosa with activity towards endogenous phospholipids affects biofilm assembly.
Weiler AJ, Spitz O, Gudzuhn M, Schott-Verdugo SN, Kamel M, Thiele B, Streit WR, Kedrov A, Schmitt L, Gohlke H, Kovacic F
Biochim Biophys Acta Mol Cell Biol Lipids 2022 Apr;1867(4):159101
PubMed ID: 35063652