Pseudomonas aeruginosa PAO1, PA3746 (ffh)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3746
Name
ffh
Replicon chromosome
Genomic location 4197169 - 4198542 (- strand)
Transposon Mutants 1 transposon mutants in PAO1

Cross-References

RefSeq NP_252435.1
GI 15598941
Affymetrix PA3746_ffh_at
Entrez 880310
GenBank AAG07133.1
INSDC AAG07133.1
NCBI Locus Tag PA3746
protein_id(GenBank) gb|AAG07133.1|AE004793_10|gnl|PseudoCAP|PA3746
TIGR NTL03PA03746
UniParc UPI00000C5AED
UniProtKB Acc Q9HXP8
UniProtKB ID Q9HXP8_PSEAE
UniRef100 UniRef100_W0YX68
UniRef50 UniRef50_P0AGD9
UniRef90 UniRef90_Q4KHQ9

Product

Feature Type CDS
Coding Frame 1
Product Name
signal recognition particle protein Ffh
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 14.23
Kyte-Doolittle Hydrophobicity Value -0.176
Molecular Weight (kDa) 49.4
Isoelectric Point (pI) 10.33

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 664 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001936 (537 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3746
Search term: ffh

Human Homologs

Ensembl 110, assembly GRCh38.p14
signal recognition particle 54 [Source:HGNC Symbol;Acc:HGNC:11301]
E-value: 1.5e-42
Percent Identity: 29.7
Ensembl 110, assembly GRCh38.p14
signal recognition particle 54 [Source:HGNC Symbol;Acc:HGNC:11301]
E-value: 1.5e-42
Percent Identity: 29.7
Ensembl 110, assembly GRCh38.p14
signal recognition particle 54 [Source:HGNC Symbol;Acc:HGNC:11301]
E-value: 1.5e-42
Percent Identity: 29.7
Ensembl 110, assembly GRCh38.p14
signal recognition particle 54 [Source:HGNC Symbol;Acc:HGNC:11301]
E-value: 1.5e-42
Percent Identity: 29.7

References

E. coli 4.5S RNA is part of a ribonucleoprotein particle that has properties related to signal recognition particle.
Ribes V, Römisch K, Giner A, Dobberstein B, Tollervey D
Cell 1990 Nov 2;63(3):591-600
PubMed ID: 2171778
The E. coli ffh gene is necessary for viability and efficient protein export.
Phillips GJ, Silhavy TJ
Nature 1992 Oct 22;359(6397):744-6
PubMed ID: 1331806
Structure of a methionine-rich segment of Escherichia coli Ffh protein.
Oh DB, Yi GS, Chi SW, Kim H
FEBS Lett 1996 Oct 21;395(2-3):160-4
PubMed ID: 8898086