Pseudomonas aeruginosa PAO1, PA4210 (phzA1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4210
Name
phzA1
Replicon chromosome
Genomic location 4713796 - 4714284 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252899.1
GI 15599405
Affymetrix PA4210_s_at
DNASU PaCD00007829
Entrez 880515
GenBank AAG07597.1
INSDC AAG07597.1
NCBI Locus Tag PA4210
protein_id(GenBank) gb|AAG07597.1|AE004838_1|gnl|PseudoCAP|PA4210
TIGR NTL03PA04210
UniParc UPI00000C5C76
UniProtKB Acc Q9HWH1
UniProtKB ID PHZA1_PSEAE
UniRef100 UniRef100_Q9HWH1
UniRef50 UniRef50_Q02L47
UniRef90 UniRef90_Q9I2J9

Product

Feature Type CDS
Coding Frame 1
Product Name
probable phenazine biosynthesis protein
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 2.32
Kyte-Doolittle Hydrophobicity Value -0.823
Molecular Weight (kDa) 19.2
Isoelectric Point (pI) 7.99

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB
Category Phenazine biosynthesis
Evidence
Host Organism
Notes
Reference

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 6 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001497 (289 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4210
Search term: phzA1

Human Homologs

References

Functional analysis of genes for biosynthesis of pyocyanin and phenazine-1-carboxamide from Pseudomonas aeruginosa PAO1.
Mavrodi DV, Bonsall RF, Delaney SM, Soule MJ, Phillips G, Thomashow LS
J Bacteriol 2001 Nov;183(21):6454-65
PubMed ID: 11591691