Pseudomonas aeruginosa PAO1, PA4732 (pgi)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4732
Name
pgi
Replicon chromosome
Genomic location 5313676 - 5315340 (+ strand)
Transposon Mutants 4 transposon mutants in PAO1

Cross-References

RefSeq NP_253420.1
GI 15599926
Affymetrix PA4732_pgi_at
Entrez 881638
GenBank AAG08118.1
INSDC AAG08118.1
NCBI Locus Tag PA4732
protein_id(GenBank) gb|AAG08118.1|AE004887_2|gnl|PseudoCAP|PA4732
TIGR NTL03PA04733
UniParc UPI000012AF66
UniProtKB Acc Q9HV67
UniProtKB ID G6PI_PSEAE
UniRef100 UniRef100_B7V1E4
UniRef50 UniRef50_A6W2I5
UniRef90 UniRef90_B7V1E4

Product

Feature Type CDS
Coding Frame 1
Product Name
glucose-6-phosphate isomerase
Product Name Confidence: Class 2
Synonyms phosphohexomutase
Evidence for Translation
Detected by MALDI-TOF/TOF (PMID:19333994).
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -5.05
Kyte-Doolittle Hydrophobicity Value -0.200
Molecular Weight (kDa) 61.9
Isoelectric Point (pI) 6.55

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 488 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004379 (534 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4732
Search term: pgi

Human Homologs

Ensembl 110, assembly GRCh38.p14
glucose-6-phosphate isomerase [Source:HGNC Symbol;Acc:HGNC:4458]
E-value: 4.9e-157
Percent Identity: 49.6
Ensembl 110, assembly GRCh38.p14
glucose-6-phosphate isomerase [Source:HGNC Symbol;Acc:HGNC:4458]
E-value: 4.9e-157
Percent Identity: 49.6

References

Phosphoglucose isomerase from Escherischia coli K 10: purification, properties and formation under aerobic and anaerobic condition.
Schreyer R, Böck A
Arch Microbiol 1980 Oct;127(3):289-98
PubMed ID: 7004378
Isolation and characterization of the phosphoglucose isomerase gene from Escherichia coli.
Froman BE, Tait RC, Gottlieb LD
Mol Gen Genet 1989 May;217(1):126-31
PubMed ID: 2549364
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994