Pseudomonas aeruginosa PAO1, PA4785

Gene Feature Overview

Strain	Pseudomonas aeruginosa PAO1 (Stover et al., 2000) GCF_000006765.1|latest
Locus Tag	PA4785
Name
Replicon	chromosome
Genomic location	5372591 - 5373868 (- strand)
Transposon Mutants	5 transposon mutants in PAO1
Transposon Mutants in orthologs	2 transposon mutants in orthologs

Cross-References

RefSeq	NP_253473.1
GI	15599979
Affymetrix	PA4785_at
Entrez	880568
GenBank	AAG08171.1
INSDC	AAG08171.1
NCBI Locus Tag	PA4785
protein_id(GenBank)	gb|AAG08171.1|AE004892_2|gnl|PseudoCAP|PA4785
TIGR	NTL03PA04786
UniParc	UPI00000C5E04
UniProtKB Acc	Q9HV23
UniProtKB ID	Q9HV23_PSEAE
UniRef100	UniRef100_W0Z0L4
UniRef50	UniRef50_O86361
UniRef90	UniRef90_A0A024HPR1

Product

Feature Type	CDS
Coding Frame	1
Product Name	probable acyl-CoA thiolase Product Name Confidence: Class 3
Synonyms
Evidence for Translation	Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7)	0.52
Kyte-Doolittle Hydrophobicity Value	-0.153
Molecular Weight (kDa)	45.9
Isoelectric Point (pI)	7.16

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 2 Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 466 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG004423 (494 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA4785 Search term: probable acyl-CoA thiolase

Human Homologs

Ensembl 110, assembly GRCh38.p14	ENSP00000442665 hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta [Source:HGNC Symbol;Acc:HGNC:4803] E-value: 3.6e-67 Percent Identity: 36.2
Ensembl 110, assembly GRCh38.p14	ENSP00000325136 hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta [Source:HGNC Symbol;Acc:HGNC:4803] E-value: 3.6e-67 Percent Identity: 36.2

References