Pseudomonas aeruginosa PAO1, PA5267 (hcpB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5267
Name
hcpB
Replicon chromosome
Genomic location 5932877 - 5933395 (- strand)
Transposon Mutants in orthologs 7 transposon mutants in orthologs

Cross-References

RefSeq NP_253954.1
GI 15600460
DNASU PaCD00008272
Entrez 879579
GenBank AAG08652.1
NCBI Locus Tag PA5267
protein_id(GenBank) gb|AAG08652.1|AE004939_4|gnl|PseudoCAP|PA5267
TIGR NTL03PA05268
UniProtKB Acc Q9HI36
UniProtKB ID MAJE_PSEAE

Product

Feature Type CDS
Coding Frame 1
Product Name
secreted protein Hcp
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -5.88
Kyte-Doolittle Hydrophobicity Value -0.449
Molecular Weight (kDa) 19.1
Isoelectric Point (pI) 5.76

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3HE1 structural genomics, unknown function 05/07/09 Secreted protein Hcp3 from Pseudomonas aeruginosa. Pseudomonas aeruginosa 2.098 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 67 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000260 (995 members)
Putative Inparalogs 1 predicted inparalogs
secreted protein Hcp (PA0263) 100.0% identity

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5267
Search term: hcpB

Human Homologs

References

Vibrio cholerae Hcp, a secreted protein coregulated with HlyA.
Williams SG, Varcoe LT, Attridge SR, Manning PA
Infect Immun 1996 Jan;64(1):283-9
PubMed ID: 8557353
Rhs elements comprise three subfamilies which diverged prior to acquisition by Escherichia coli.
Wang YD, Zhao S, Hill CW
J Bacteriol 1998 Aug;180(16):4102-10
PubMed ID: 9696756