Pseudomonas aeruginosa PAK, PAK_00612 (pilT)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa PAK - Assembly GCF_000408865.1
GCF_000408865.1|latest |
| Locus Tag |
PAK_00612
|
| Name |
pilT
|
| Replicon | chromosome |
| Genomic location | 659931 - 661079 (+ strand) |
Cross-References
| RefSeq | WP_003100959.1 |
| GI | 489191604 |
| NCBI Locus Tag | PAK_00612 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
twitching motility protein PilT
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -1.19 |
| Kyte-Doolittle Hydrophobicity Value | -0.236 |
| Molecular Weight (kDa) | 42.5 |
| Isoelectric Point (pI) | 6.80 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Virulence Evidence
| Source 1 | |
| Database | PseudoCAP |
| Category | Type IV pili biosynthesis |
| Evidence |
|
| Host Organism | |
| Notes | |
| Reference | 10377148 |
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG000387 (415 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PAK_00612
Search term: pilT
Search term: twitching motility protein PilT
|
Human Homologs
References
|
Pseudomonas aeruginosa gene products PilT and PilU are required for cytotoxicity in vitro and virulence in a mouse model of acute pneumonia.
Comolli JC, Hauser AR, Waite L, Whitchurch CB, Mattick JS, Engel JN
Infect Immun 1999 Jul;67(7):3625-30
PubMed ID: 10377148
|