Pseudomonas aeruginosa PAO1, PA0680 (hxcV)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0680
Name
hxcV
Replicon chromosome
Genomic location 738111 - 738485 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
CommentHxc proteins are involved in the secretion of alkaline phosphatase. hxc gene cluster is under phosphate regulation. Belongs to the GspI family (general secretory pathway).

Cross-References

RefSeq NP_249371.1
GI 15595877
Affymetrix PA0680_at
DNASU PaCD00006311
Entrez 880812
GenBank AAG04069.1
INSDC AAG04069.1
NCBI Locus Tag PA0680
protein_id(GenBank) gb|AAG04069.1|AE004503_7|gnl|PseudoCAP|PA0680
TIGR NTL03PA00681
UniParc UPI00000C50F9
UniProtKB Acc Q9I5P5
UniProtKB ID Q9I5P5_PSEAE
UniRef100 UniRef100_W0Z4J3
UniRef50 UniRef50_I4XVK7
UniRef90 UniRef90_W0Z4J3

Product

Feature Type CDS
Coding Frame 1
Product Name
HxcV
Product Name Confidence: Class 1
Synonyms HxcV putative pseudopilin
Evidence for Translation
Charge (pH 7) 2.93
Kyte-Doolittle Hydrophobicity Value 0.223
Molecular Weight (kDa) 13.4
Isoelectric Point (pI) 9.53

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 51 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000659 (375 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0680
Search term: hxcV
Search term: HxcV

Human Homologs

References

A novel type II secretion system in Pseudomonas aeruginosa.
Ball G, Durand E, Lazdunski A, Filloux A
Mol Microbiol 2002 Jan;43(2):475-85
PubMed ID: 11985723
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295