Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA0907
|
Name |
alpA
|
Replicon | chromosome |
Genomic location | 992714 - 993244 (+ strand) |
Transposon Mutants | 1 transposon mutants in PAO1 |
Comment | Activator of the alp lysis genes |
RefSeq | NP_249598.1 |
GI | 15596104 |
Affymetrix | PA0907_at |
DNASU | PaCD00006418 |
Entrez | 878349 |
GenBank | AAG04296.1 |
INSDC | AAG04296.1 |
NCBI Locus Tag | PA0907 |
protein_id(GenBank) | gb|AAG04296.1|AE004525_4|gnl|PseudoCAP|PA0907 |
TIGR | NTL03PA00908 |
UniParc | UPI00000C51AE |
UniProtKB Acc | Q9I550 |
UniProtKB ID | Q9I550_PSEAE |
UniRef100 | UniRef100_W0YMZ6 |
UniRef50 | UniRef50_W0YMZ6 |
UniRef90 | UniRef90_W0YMZ6 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
lysis phenotype activator, AlpA
|
Synonyms |
hypothetical protein |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | 4.20 |
Kyte-Doolittle Hydrophobicity Value | -0.290 |
Molecular Weight (kDa) | 20.2 |
Isoelectric Point (pI) | 10.42 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
7XYB | TRANSCRIPTION | 06/01/22 | The cryo-EM structure of an AlpA-loaded complex | Pseudomonas aeruginosa; SYNTHETIC CONSTRUCT | 3.7 | ELECTRON MICROSCOPY | 93.1 |
7XYA | TRANSCRIPTION | 06/01/22 | The cryo-EM structure of an AlpA-loading complex | Pseudomonas aeruginosa; SYNTHETIC CONSTRUCT | 3.3 | ELECTRON MICROSCOPY | 93.1 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 3 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG000873 (301 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA0907
Search term: alpA
Search term: lysis phenotype activator, AlpA
|
A self-lysis pathway that enhances the virulence of a pathogenic bacterium.
McFarland KA, Dolben EL, LeRoux M, Kambara TK, Ramsey KM, Kirkpatrick RL, Mougous JD, Hogan DA, Dove SL
Proc Natl Acad Sci U S A 2015 Jul 7;112(27):8433-8
PubMed ID: 26100878
|