Pseudomonas aeruginosa PAO1, PA0910 (alpD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA0910
Name
alpD
Replicon chromosome
Genomic location 994143 - 994646 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249601.1
GI 15596107
Affymetrix PA0910_at
DNASU PaCD00006421
Entrez 877763
GenBank AAG04299.1
INSDC AAG04299.1
NCBI Locus Tag PA0910
protein_id(GenBank) gb|AAG04299.1|AE004525_7|gnl|PseudoCAP|PA0910
TIGR NTL03PA00911
UniParc UPI00000C51B1
UniProtKB Acc Q9I547
UniProtKB ID Q9I547_PSEAE
UniRef100 UniRef100_Q9I547
UniRef50 UniRef50_Q9I547
UniRef90 UniRef90_Q9I547

Product

Feature Type CDS
Coding Frame 1
Product Name
AlpD
Product Name Confidence: Class 1
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.87
Kyte-Doolittle Hydrophobicity Value 0.032
Molecular Weight (kDa) 17.9
Isoelectric Point (pI) 6.35

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 3 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000876 (308 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0910
Search term: alpD
Search term: AlpD

Transposon Insertions in PAO1

Type Confirmed ISphoA/hah insertion site
Mutant ID UWGC: 52638
Genomic Position 994538
Position in ORF 396(504)
Reference 14617778

Transposon Insertions in Orthologs

Type MAR2xT7 transposon (wild type background) insertion site
Strain Pseudomonas aeruginosa UCBPP-PA14
Locus Tag PA14_52490
Mutant ID PA14NR: 40561
Genomic Position 4656957
Position in ORF 14(504)
Reference 16477005

References

A self-lysis pathway that enhances the virulence of a pathogenic bacterium.
McFarland KA(1), Dolben EL(2), LeRoux M(3), Kambara TK(1), Ramsey KM(1), Kirkpatrick RL(4), Mougous JD(4), Hogan DA(2), Dove SL(5).
Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8433-8.
PubMed ID: 26100878