Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA1706
|
Name |
pcrV
|
Replicon | chromosome |
Genomic location | 1852288 - 1853172 (+ strand) |
Transposon Mutants | 2 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
RefSeq | NP_250397.1 |
GI | 15596903 |
Affymetrix | PA1706_pcrV_at |
Entrez | 882997 |
GenBank | AAG05095.1 |
INSDC | AAG05095.1 |
NCBI Locus Tag | PA1706 |
protein_id(GenBank) | gb|AAG05095.1|AE004597_9|gnl|PseudoCAP|PA1706 |
TIGR | NTL03PA01707 |
UniParc | UPI00000D424F |
UniProtKB Acc | G3XD49 |
UniProtKB ID | G3XD49_PSEAE |
UniRef100 | UniRef100_W0YNT8 |
UniRef50 | UniRef50_Q02KJ7 |
UniRef90 | UniRef90_Q02KJ7 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
type III secretion protein PcrV
|
Synonyms | |
Evidence for Translation | |
Charge (pH 7) | -7.51 |
Kyte-Doolittle Hydrophobicity Value | -0.257 |
Molecular Weight (kDa) | 32.3 |
Isoelectric Point (pI) | 4.77 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
6CYF | IMMUNE SYSTEM | 04/05/18 | PcrV fragment with bound Fab | homo sapiens; Pseudomonas aeruginosa | 2.78 | X-RAY DIFFRACTION | 96.7 |
Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.
Drug Name | Source Accession | Source DB | Version | Target Accession | Target Description | Percent Identity | Alignment Length | E-Value |
KB001 | DB05222 | DrugBank | 5.1.4 | O30527 | Low calcium response locus protein V | 100.0 | 294 | 5.4e-158 |
Source 1 | |
Database | VFDB : VF0083 |
Category | T3SS |
Evidence |
|
Host Organism | |
Notes | |
Reference | 11372029 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 5 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG003683 (315 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA1706
Search term: pcrV
Search term: type III secretion protein PcrV
|
LcrV is a channel size-determining component of the Yop effector translocon of Yersinia.
Holmström A, Olsson J, Cherepanov P, Maier E, Nordfelth R, Pettersson J, Benz R, Wolf-Watz H, Forsberg A
Mol Microbiol 2001 Feb;39(3):620-32
PubMed ID: 11169103
|
Identification of type III secreted products of the Pseudomonas aeruginosa exoenzyme S regulon.
Yahr TL, Mende-Mueller LM, Friese MB, Frank DW
J Bacteriol 1997 Nov;179(22):7165-8
PubMed ID: 9371466
|
Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury.
Sawa T, Yahr TL, Ohara M, Kurahashi K, Gropper MA, Wiener-Kronish JP, Frank DW
Nat Med 1999 Apr;5(4):392-8
PubMed ID: 10202927
|
The V antigen of Pseudomonas aeruginosa is required for assembly of the functional PopB/PopD translocation pore in host cell membranes.
Goure J, Pastor A, Faudry E, Chabert J, Dessen A, Attree I
Infect Immun 2004 Aug;72(8):4741-50
PubMed ID: 15271936
|
Mep72, a metzincin protease that is preferentially secreted by biofilms of Pseudomonas aeruginosa.
Passmore IJ, Nishikawa K, Lilley KS, Bowden SD, Chung JC, Welch M
J Bacteriol 2015 Feb 15;197(4):762-73
PubMed ID: 25488299
|