Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA1714
|
Name |
exsD
|
Replicon | chromosome |
Genomic location | 1858207 - 1859037 (+ strand) |
Transposon Mutants | 1 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 2 transposon mutants in orthologs |
Comment | ExsD inhibits transcription of the type III secretion system by binding to and inhibiting ExsA-dependent transcription. ExsD is classified as an anti-activator. |
RefSeq | NP_250405.1 |
GI | 15596911 |
Affymetrix | PA1714_at |
DNASU | PaCD00006776 |
Entrez | 880880 |
GenBank | AAG05103.1 |
INSDC | AAG05103.1 |
NCBI Locus Tag | PA1714 |
protein_id(GenBank) | gb|AAG05103.1|AE004598_2|gnl|PseudoCAP|PA1714 |
TIGR | NTL03PA01715 |
UniParc | UPI00000C5459 |
UniProtKB Acc | Q9I321 |
UniProtKB ID | Q9I321_PSEAE |
UniRef100 | UniRef100_W0YMR8 |
UniRef50 | UniRef50_P95429 |
UniRef90 | UniRef90_P95429 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
ExsD
|
Synonyms | |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -6.72 |
Kyte-Doolittle Hydrophobicity Value | -0.333 |
Molecular Weight (kDa) | 31.4 |
Isoelectric Point (pI) | 4.87 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
3FD9 | UNKNOWN FUNCTION | 11/25/08 | Crystal Structure of the transcriptional anti-activator ExsD from Pseudomonas aeruginosa | Pseudomonas aeruginosa UCBPP-PA14 | 2.6 | X-RAY DIFFRACTION | 99.2 |
Source 1 | |
Database | VFDB : VF0083 |
Category | T3SS |
Evidence |
|
Host Organism | |
Notes | |
Reference | 11372029 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 5 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG003675 (309 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA1714
Search term: exsD
Search term: ExsD
|
ExsD is a negative regulator of the Pseudomonas aeruginosa type III secretion regulon.
McCaw ML, Lykken GL, Singh PK, Yahr TL
Mol Microbiol 2002 Nov;46(4):1123-33
PubMed ID: 12421316
|
Exoenzyme S of Pseudomonas aeruginosa is secreted by a type III pathway.
Yahr TL, Goranson J, Frank DW
Mol Microbiol 1996 Dec;22(5):991-1003
PubMed ID: 8971719
|