Pseudomonas aeruginosa PAO1, PA1951 (fapF)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1951
Name
fapF
Replicon chromosome
Genomic location 2136520 - 2137785 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq NP_250641.1
GI 15597147
Affymetrix PA1951_at
Entrez 880745
GenBank AAG05339.1
INSDC AAG05339.1
NCBI Locus Tag PA1951
protein_id(GenBank) gb|AAG05339.1|AE004622_1|gnl|PseudoCAP|PA1951
TIGR NTL03PA01951
UniParc UPI00000C5527
UniProtKB Acc Q9I2F3
UniProtKB ID Q9I2F3_PSEAE
UniRef100 UniRef100_W0YNJ3
UniRef50 UniRef50_I4XVM8
UniRef90 UniRef90_W0YNJ3

Product

Feature Type CDS
Coding Frame 1
Product Name
FapF
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -9.79
Kyte-Doolittle Hydrophobicity Value -0.226
Molecular Weight (kDa) 45.7
Isoelectric Point (pI) 4.57

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 40 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003481 (782 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1951
Search term: fapF
Search term: FapF

Human Homologs

References

Functional amyloid in Pseudomonas.
Dueholm MS, Petersen SV, Sønderkær M, Larsen P, Christiansen G, Hein KL, Enghild JJ, Nielsen JL, Nielsen KL, Nielsen PH, Otzen DE
Mol Microbiol 2010 Aug;77(4):1009-20
PubMed ID: 20572935
Expression of Fap amyloids in Pseudomonas aeruginosa, P. fluorescens, and P. putida results in aggregation and increased biofilm formation.
Dueholm MS, Søndergaard MT, Nilsson M, Christiansen G, Stensballe A, Overgaard MT, Givskov M, Tolker-Nielsen T, Otzen DE, Nielsen PH
Microbiologyopen 2013 Jun;2(3):365-82
PubMed ID: 23504942