Pseudomonas aeruginosa PAO1, PA1952 (fapE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1952
Name
fapE
Replicon chromosome
Genomic location 2137846 - 2138598 (- strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_250642.1
GI 15597148
Affymetrix PA1952_at
Entrez 880731
GenBank AAG05340.1
INSDC AAG05340.1
NCBI Locus Tag PA1952
protein_id(GenBank) gb|AAG05340.1|AE004622_2|gnl|PseudoCAP|PA1952
TIGR NTL03PA01952
UniParc UPI00000C5528
UniProtKB Acc Q9I2F2
UniProtKB ID Q9I2F2_PSEAE
UniRef100 UniRef100_Q9I2F2
UniRef50 UniRef50_Q9I2F2
UniRef90 UniRef90_Q9I2F2

Product

Feature Type CDS
Coding Frame 1
Product Name
FapE
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 0.07
Kyte-Doolittle Hydrophobicity Value 0.010
Molecular Weight (kDa) 25.6
Isoelectric Point (pI) 7.03

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 7 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003480 (464 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1952
Search term: fapE
Search term: FapE

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Functional amyloid in Pseudomonas.
Dueholm MS, Petersen SV, Sønderkær M, Larsen P, Christiansen G, Hein KL, Enghild JJ, Nielsen JL, Nielsen KL, Nielsen PH, Otzen DE
Mol Microbiol 2010 Aug;77(4):1009-20
PubMed ID: 20572935
Expression of Fap amyloids in Pseudomonas aeruginosa, P. fluorescens, and P. putida results in aggregation and increased biofilm formation.
Dueholm MS, Søndergaard MT, Nilsson M, Christiansen G, Stensballe A, Overgaard MT, Givskov M, Tolker-Nielsen T, Otzen DE, Nielsen PH
Microbiologyopen 2013 Jun;2(3):365-82
PubMed ID: 23504942