Pseudomonas aeruginosa PAO1, PA1953 (fapD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1953
Name
fapD
Replicon chromosome
Genomic location 2138612 - 2139292 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 4 transposon mutants in orthologs

Cross-References

RefSeq NP_250643.1
GI 15597149
Affymetrix PA1953_at
DNASU PaCD00006874
Entrez 880801
GenBank AAG05341.1
INSDC AAG05341.1
NCBI Locus Tag PA1953
protein_id(GenBank) gb|AAG05341.1|AE004622_3|gnl|PseudoCAP|PA1953
TIGR NTL03PA01953
UniParc UPI00000C5529
UniProtKB Acc Q9I2F1
UniProtKB ID Q9I2F1_PSEAE
UniRef100 UniRef100_Q9I2F1
UniRef50 UniRef50_G8PYP8
UniRef90 UniRef90_Q9I2F1

Product

Feature Type CDS
Coding Frame 1
Product Name
FapD
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 1.68
Kyte-Doolittle Hydrophobicity Value -0.014
Molecular Weight (kDa) 25.3
Isoelectric Point (pI) 8.40

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 135 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003479 (780 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1953
Search term: fapD
Search term: FapD

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Functional amyloid in Pseudomonas.
Dueholm MS, Petersen SV, Sønderkær M, Larsen P, Christiansen G, Hein KL, Enghild JJ, Nielsen JL, Nielsen KL, Nielsen PH, Otzen DE
Mol Microbiol 2010 Aug;77(4):1009-20
PubMed ID: 20572935
Expression of Fap amyloids in Pseudomonas aeruginosa, P. fluorescens, and P. putida results in aggregation and increased biofilm formation.
Dueholm MS, Søndergaard MT, Nilsson M, Christiansen G, Stensballe A, Overgaard MT, Givskov M, Tolker-Nielsen T, Otzen DE, Nielsen PH
Microbiologyopen 2013 Jun;2(3):365-82
PubMed ID: 23504942