Pseudomonas aeruginosa PAO1, PA2133

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2133
Name
Replicon chromosome
Genomic location 2348538 - 2349395 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentOverexpression of PA2133 results in impaired TTSS-mediated cytotoxicity

Cross-References

RefSeq NP_250823.1
GI 15597329
Affymetrix PA2133_at
DNASU PaCD00006943
Entrez 877931
GenBank AAG05521.1
INSDC AAG05521.1
NCBI Locus Tag PA2133
protein_id(GenBank) gb|AAG05521.1|AE004640_10|gnl|PseudoCAP|PA2133
TIGR NTL03PA02133
UniParc UPI00000C55C3
UniProtKB Acc Q9I1Y2
UniProtKB ID Q9I1Y2_PSEAE
UniRef100 UniRef100_Q9I1Y2
UniRef50 UniRef50_Q9I1Y2
UniRef90 UniRef90_Q9I1Y2

Product

Feature Type CDS
Coding Frame 1
Product Name
Cyclic-guanylate-specific phosphodiesterase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 8.51
Kyte-Doolittle Hydrophobicity Value -0.238
Molecular Weight (kDa) 31.9
Isoelectric Point (pI) 9.46

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 381 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003342 (313 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2133

Human Homologs

References

Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3'-5')-cyclic-GMP in virulence.
Kulasakara H, Lee V, Brencic A, Liberati N, Urbach J, Miyata S, Lee DG, Neely AN, Hyodo M, Hayakawa Y, Ausubel FM, Lory S
Proc Natl Acad Sci U S A 2006 Feb 21;103(8):2839-44
PubMed ID: 16477007