Pseudomonas aeruginosa PAO1, PA2204

Gene Feature Overview

Strain	Pseudomonas aeruginosa PAO1 (Stover et al., 2000) GCF_000006765.1|latest
Locus Tag	PA2204
Name
Replicon	chromosome
Genomic location	2422819 - 2423625 (- strand)
Transposon Mutants	2 transposon mutants in PAO1
Transposon Mutants in orthologs	1 transposon mutants in orthologs
Comment	Structural similarity to 3VV5 (amino acid ABC transporter from Thermus thermophilus, root-mean-square deviation: 0.7 angstroms). Sequence similarity to 4ZV1 (89%/39,11%) (ARG). Final predicted ligand: L-amino acid (PMID: 31631799)

Cross-References

RefSeq	NP_250894.1
GI	15597400
Affymetrix	PA2204_at
DNASU	PaCD00006980
Entrez	877884
GenBank	AAG05592.1
INSDC	AAG05592.1
NCBI Locus Tag	PA2204
protein_id(GenBank)	gb|AAG05592.1|AE004647_1|gnl|PseudoCAP|PA2204
TIGR	NTL03PA02204
UniParc	UPI00000C5606
UniProtKB Acc	Q9I1R3
UniProtKB ID	Q9I1R3_PSEAE
UniRef100	UniRef100_W0YPG3
UniRef50	UniRef50_J0UYW5
UniRef90	UniRef90_A6V5W1

Product

Feature Type	CDS
Coding Frame	1
Product Name	putative binding protein component of ABC transporter Product Name Confidence: Class 3
Synonyms
Evidence for Translation	Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602). Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7)	4.00
Kyte-Doolittle Hydrophobicity Value	-0.182
Molecular Weight (kDa)	29.3
Isoelectric Point (pI)	9.65

Subcellular localization

Individual Mappings	Localization Confidence PMID Periplasmic Class 2 Periplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 473 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG001211 (994 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA2204 Search term: putative binding protein component of ABC transporter

Human Homologs

References

Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen. Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM Proteomics 2009 Apr;9(7):1901-15 PubMed ID: 19333994

Uncovering the structure and function of Pseudomonas aeruginosa periplasmic proteins by an in silico approach. Caprari S, Brandi V, Pasquadibisceglie A, Polticelli F J Biomol Struct Dyn 2020 Sep;38(15):4508-4520 PubMed ID: 31631799