Pseudomonas aeruginosa PAO1, PA2215 (lyxD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2215
Name
lyxD
Replicon chromosome
Genomic location 2435101 - 2436276 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_250905.1
GI 15597411
Affymetrix PA2215_at
DNASU PaCD00006985
Entrez 877774
GenBank AAG05603.1
INSDC AAG05603.1
NCBI Locus Tag PA2215
protein_id(GenBank) gb|AAG05603.1|AE004648_2|gnl|PseudoCAP|PA2215
TIGR NTL03PA02215
UniParc UPI00000C5610
UniProtKB Acc Q9I1Q2
UniProtKB ID Q9I1Q2_PSEAE
UniRef100 UniRef100_W0YPH3
UniRef50 UniRef50_F8GP26
UniRef90 UniRef90_F6AD85

Product

Feature Type CDS
Coding Frame 1
Product Name
l-lyxonate dehydratase LyxD
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -9.70
Kyte-Doolittle Hydrophobicity Value -0.185
Molecular Weight (kDa) 44.2
Isoelectric Point (pI) 5.33

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 342 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001643 (655 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2215
Search term: lyxD

Human Homologs

References

Discovery of a novel L-lyxonate degradation pathway in Pseudomonas aeruginosa PAO1.
Ghasempur S, Eswaramoorthy S, Hillerich BS, Seidel RD, Swaminathan S, Almo SC, Gerlt JA
Biochemistry 2014 May 27;53(20):3357-66
PubMed ID: 24831290