Pseudomonas aeruginosa PAO1, PA3204 (cpxR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA3204
Name
cpxR
Replicon chromosome
Genomic location 3594581 - 3595258 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_251894.1
GI 15598400
Affymetrix PA3204_at
Entrez 882544
GenBank AAG06592.1
INSDC AAG06592.1
NCBI Locus Tag PA3204
protein_id(GenBank) gb|AAG06592.1|AE004744_7|gnl|PseudoCAP|PA3204
TIGR NTL03PA03204
UniParc UPI00000C594A
UniProtKB Acc Q9HZ36
UniProtKB ID Q9HZ36_PSEAE
UniRef100 UniRef100_W0YUZ4
UniRef50 UniRef50_Q4KGB4
UniRef90 UniRef90_M4WZL9

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component response regulator CpxR
Product Name Confidence: Class 1
Synonyms probable two-component response regulator
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -3.62
Kyte-Doolittle Hydrophobicity Value -0.280
Molecular Weight (kDa) 24.8
Isoelectric Point (pI) 5.96

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 2
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 622 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002411 (561 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3204
Search term: cpxR

References

The cpx proteins of Escherichia coli K12. Structure of the cpxA polypeptide as an inner membrane component.
Weber RF, Silverman PM
J. Mol. Biol. 1988 Sep;203(2):467-78
PubMed ID: 3058985
CpxR Activates MexAB-OprM Efflux Pump Expression and Enhances Antibiotic Resistance in Both Laboratory and Clinical nalB-Type Isolates of Pseudomonas aeruginosa.
Tian ZX, Yi XX, Cho A, O'Gara F, Wang YP
PLoS Pathog. 2016 Oct;12(10):e1005932
PubMed ID: 27736975