Pseudomonas aeruginosa PAO1, PA3543 (algK)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA3543
Name
algK
Replicon chromosome
Genomic location 3967025 - 3968452 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_252233.1
GI 15598739
Affymetrix PA3543_algK_at
Entrez 878771
GenBank AAG06931.1
INSDC AAG06931.1
NCBI Locus Tag PA3543
protein_id(GenBank) gb|AAG06931.1|AE004775_2|gnl|PseudoCAP|PA3543
TIGR NTL03PA03543
UniParc UPI00000D429B
UniProtKB Acc P96956
UniProtKB ID ALGK_PSEAE
UniRef100 UniRef100_P96956
UniRef50 UniRef50_P96956
UniRef90 UniRef90_P96956

Product

Feature Type CDS
Coding Frame 1
Product Name
alginate biosynthetic protein AlgK precursor
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -4.88
Kyte-Doolittle Hydrophobicity Value -0.432
Molecular Weight (kDa) 52.5
Isoelectric Point (pI) 5.56

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 1
Periplasmic Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database VFDB : VF0091
Category Alginate biosynthesis
Evidence
Host Organism
Notes
Reference

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 26 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002123 (513 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3543
Search term: algK

References

A novel gene, algK, from the alginate biosynthesis cluster of Pseudomonas aeruginosa.
Aarons SJ, Sutherland IW, Chakrabarty AM, Gallagher MP
Microbiology (Reading, Engl.) 1997 Feb;143 ( Pt 2)
PubMed ID: 9043140
Deletion of algK in mucoid Pseudomonas aeruginosa blocks alginate polymer formation and results in uronic acid secretion.
Jain S, Ohman DE
J. Bacteriol. 1998 Feb;180(3):634-41
PubMed ID: 9457868