Pseudomonas aeruginosa PAO1, PA4195

Gene Feature Overview

Strain	Pseudomonas aeruginosa PAO1 (Stover et al., 2000) GCF_000006765.1|latest
Locus Tag	PA4195
Name
Replicon	chromosome
Genomic location	4692126 - 4692956 (- strand)
Transposon Mutants	3 transposon mutants in PAO1
Transposon Mutants in orthologs	1 transposon mutants in orthologs
Comment	Structural similarity to 2YJP (solute receptors for L-cysteine from Neisseria gonorrhoeae, root-mean-square deviation: 1.4 angstroms). Sequence similarity to 4ZV1 (88%/35,24%) (ARG). Final predicted ligand: L-amino acid (PMID: 31631799)

Cross-References

RefSeq	NP_252884.1
GI	15599390
Affymetrix	PA4195_at
Entrez	880469
GenBank	AAG07582.1
INSDC	AAG07582.1
NCBI Locus Tag	PA4195
protein_id(GenBank)	gb|AAG07582.1|AE004836_1|gnl|PseudoCAP|PA4195
TIGR	NTL03PA04195
UniParc	UPI00000C5C68
UniProtKB Acc	Q9HWI6
UniProtKB ID	Q9HWI6_PSEAE
UniRef100	UniRef100_Q9HWI6
UniRef50	UniRef50_A0A093U4W1
UniRef90	UniRef90_Q9HWI6

Product

Feature Type	CDS
Coding Frame	1
Product Name	putative amino acid ABC transporter substrate-binding protein Product Name Confidence: Class 3
Synonyms
Evidence for Translation	Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7)	1.20
Kyte-Doolittle Hydrophobicity Value	-0.103
Molecular Weight (kDa)	29.5
Isoelectric Point (pI)	7.87

Subcellular localization

Individual Mappings	Localization Confidence PMID Periplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 435 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG001211 (994 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA4195 Search term: putative amino acid ABC transporter substrate-binding protein

Human Homologs

References

Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen. Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM Proteomics 2009 Apr;9(7):1901-15 PubMed ID: 19333994

Uncovering the structure and function of Pseudomonas aeruginosa periplasmic proteins by an in silico approach. Caprari S, Brandi V, Pasquadibisceglie A, Polticelli F J Biomol Struct Dyn 2020 Sep;38(15):4508-4520 PubMed ID: 31631799