Pseudomonas aeruginosa PAO1, PA4208 (opmD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4208
Name
opmD
Replicon chromosome
Genomic location 4710621 - 4712084 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252897.1
GI 15599403
Affymetrix PA4208_at
Entrez 880347
GenBank AAG07595.1
INSDC AAG07595.1
NCBI Locus Tag PA4208
protein_id(GenBank) gb|AAG07595.1|AE004837_6|gnl|PseudoCAP|PA4208
TIGR NTL03PA04208
UniParc UPI0000001FD9
UniProtKB Acc Q9HWH3
UniProtKB ID Q9HWH3_PSEAE
UniRef100 UniRef100_G3XCL5
UniRef50 UniRef50_Q02T25
UniRef90 UniRef90_Q02T25

Product

Feature Type CDS
Coding Frame 1
Product Name
probable outer membrane protein precursor
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -4.04
Kyte-Doolittle Hydrophobicity Value -0.282
Molecular Weight (kDa) 53.0
Isoelectric Point (pI) 5.62

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 3
Outer Membrane Class 2
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
OpmD OpmD is the outer membrane channel protein of the efflux complex MexGHI-OpmD. [PMID:12937010, PMID:12917802, PMID:15817779, PMID:12177331] ARO:3000809 protein homolog model Perfect 932.9 100.0 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 289 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001499 (305 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4208
Search term: opmD

Human Homologs

References

Characterization of a new efflux pump, MexGHI-OpmD, from Pseudomonas aeruginosa that confers resistance to vanadium.
Aendekerk S, Ghysels B, Cornelis P, Baysse C
Microbiology (Reading) 2002 Aug;148(Pt 8):2371-2381
PubMed ID: 12177331
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Characterization of MexE-MexF-OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa.
Köhler T, Michéa-Hamzehpour M, Henze U, Gotoh N, Curty LK, Pechère JC
Mol Microbiol 1997 Jan;23(2):345-54
PubMed ID: 9044268