Pseudomonas aeruginosa PAO1, PA4351 (olsA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4351
Name
olsA
Replicon chromosome
Genomic location 4879545 - 4880321 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253041.1
GI 15599547
Affymetrix PA4351_at
Entrez 881447
GenBank AAG07739.1
INSDC AAG07739.1
NCBI Locus Tag PA4351
protein_id(GenBank) gb|AAG07739.1|AE004851_7|gnl|PseudoCAP|PA4351
TIGR NTL03PA04352
UniParc UPI00000C5CD6
UniProtKB Acc Q9HW50
UniProtKB ID Q9HW50_PSEAE
UniRef100 UniRef100_U8M486
UniRef50 UniRef50_Q48EK8
UniRef90 UniRef90_A6VB23

Product

Feature Type CDS
Coding Frame 1
Product Name
OlsA
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 13.17
Kyte-Doolittle Hydrophobicity Value 0.018
Molecular Weight (kDa) 28.3
Isoelectric Point (pI) 11.98

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 319 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003944 (529 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4351
Search term: olsA
Search term: OlsA

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Membrane glycerophospholipid biosynthesis in Neisseria meningitidis and Neisseria gonorrhoeae: identification, characterization, and mutagenesis of a lysophosphatidic acid acyltransferase.
Swartley JS, Balthazar JT, Coleman J, Shafer WM, Stephens DS
Mol Microbiol 1995 Nov;18(3):401-12
PubMed ID: 8748025
Multiple lysophosphatidic acid acyltransferases in Neisseria meningitidis.
Shih GC, Kahler CM, Swartley JS, Rahman MM, Coleman J, Carlson RW, Stephens DS
Mol Microbiol 1999 Jun;32(5):942-52
PubMed ID: 10361297
The olsA gene mediates the synthesis of an ornithine lipid in Pseudomonas aeruginosa during growth under phosphate-limiting conditions, but is not involved in antimicrobial peptide susceptibility.
Lewenza S, Falsafi R, Bains M, Rohs P, Stupak J, Sprott GD, Hancock RE
FEMS Microbiol Lett 2011 Jul;320(2):95-102
PubMed ID: 21535098
Identification of a gene required for the formation of lyso-ornithine lipid, an intermediate in the biosynthesis of ornithine-containing lipids.
Gao JL, Weissenmayer B, Taylor AM, Thomas-Oates J, López-Lara IM, Geiger O
Mol Microbiol 2004 Sep;53(6):1757-70
PubMed ID: 15341653