Pseudomonas aeruginosa PAO1, PA4380 (colS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4380
Name
colS
Replicon chromosome
Genomic location 4910871 - 4912151 (- strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_253070.1
GI 15599576
Affymetrix PA4380_at
Entrez 881359
GenBank AAG07768.1
INSDC AAG07768.1
NCBI Locus Tag PA4380
protein_id(GenBank) gb|AAG07768.1|AE004854_4|gnl|PseudoCAP|PA4380
TIGR NTL03PA04381
UniParc UPI00000C5CF0
UniProtKB Acc Q9HW22
UniProtKB ID Q9HW22_PSEAE
UniRef100 UniRef100_W0YXC3
UniRef50 UniRef50_Q4K767
UniRef90 UniRef90_A6VB52

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component sensor ColS
Product Name Confidence: Class 1
Synonyms probable two-component sensor
Evidence for Translation
Charge (pH 7) -15.69
Kyte-Doolittle Hydrophobicity Value -0.024
Molecular Weight (kDa) 46.9
Isoelectric Point (pI) 4.84

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 619 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003970 (528 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4380
Search term: colS

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
A two-component system plays an important role in the root-colonizing ability of Pseudomonas fluorescens strain WCS365.
Dekkers LC, Bloemendaal CJ, de Weger LA, Wijffelman CA, Spaink HP, Lugtenberg BJ
Mol Plant Microbe Interact 1998 Jan;11(1):45-56
PubMed ID: 9425686
Polymyxin resistance of Pseudomonas aeruginosa phoQ mutants is dependent on additional two-component regulatory systems.
Gutu AD, Sgambati N, Strasbourger P, Brannon MK, Jacobs MA, Haugen E, Kaul RK, Johansen HK, Høiby N, Moskowitz SM
Antimicrob Agents Chemother 2013 May;57(5):2204-15
PubMed ID: 23459479