Pseudomonas aeruginosa PAO1, PA4488 (magE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4488
Name
magE
Replicon chromosome
Genomic location 5018756 - 5020405 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253178.1
GI 15599684
Affymetrix PA4488_at
Entrez 881219
GenBank AAG07876.1
INSDC AAG07876.1
NCBI Locus Tag PA4488
protein_id(GenBank) gb|AAG07876.1|AE004862_10|gnl|PseudoCAP|PA4488
TIGR NTL03PA04489
UniParc UPI00000C5D32
UniProtKB Acc Q9HVT3
UniProtKB ID Q9HVT3_PSEAE
UniRef100 UniRef100_Q9HVT3
UniRef50 UniRef50_P76463
UniRef90 UniRef90_W0WN08

Product

Feature Type CDS
Coding Frame 1
Product Name
MagE
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 7.91
Kyte-Doolittle Hydrophobicity Value -0.360
Molecular Weight (kDa) 61.7
Isoelectric Point (pI) 8.60

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 1
Unknown (This protein may have multiple localization sites) Class 3
Unknown (This protein may have multiple localization sites) Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database Victors : 4253
Category
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Rattus norvegicus
Notes
Infection model Rat agar bead model of chronic lung infection
Reference 14641575

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 9 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004076 (357 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4488
Search term: magE
Search term: MagE

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Unique features of a Pseudomonas aeruginosa α2-macroglobulin homolog.
Robert-Genthon M, Casabona MG, Neves D, Couté Y, Cicéron F, Elsen S, Dessen A, Attrée I
MBio 2013 Aug;4(4):
PubMed ID: 23919994