Pseudomonas aeruginosa PAO1, PA4707 (phuU)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4707
Name
phuU
Synonym: phuU
Replicon chromosome
Genomic location 5286035 - 5287018 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253395.1
GI 15599901
Affymetrix PA4707_at
Entrez 881537
GenBank AAG08093.1
INSDC AAG08093.1
NCBI Locus Tag PA4707
protein_id(GenBank) gb|AAG08093.1|AE004884_11|gnl|PseudoCAP|PA4707
TIGR NTL03PA04708
UniParc UPI00000C5DD5
UniProtKB Acc Q9HV91
UniProtKB ID Q9HV91_PSEAE
UniRef100 UniRef100_W0YXD7
UniRef50 UniRef50_G8QCQ5
UniRef90 UniRef90_O68878

Product

Feature Type CDS
Coding Frame 1
Product Name
PhuU
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 4.62
Kyte-Doolittle Hydrophobicity Value 1.027
Molecular Weight (kDa) 33.6
Isoelectric Point (pI) 9.24

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 2
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 552 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002661 (994 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4707
Search term: phuU
Search term: PhuU

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Transport of haemin across the cytoplasmic membrane through a haemin-specific periplasmic binding-protein-dependent transport system in Yersinia enterocolitica.
Stojiljkovic I, Hantke K
Mol Microbiol 1994 Aug;13(4):719-32
PubMed ID: 7997183
Gene repression by the ferric uptake regulator in Pseudomonas aeruginosa: cycle selection of iron-regulated genes.
Ochsner UA, Vasil ML
Proc Natl Acad Sci U S A 1996 Apr 30;93(9):4409-14
PubMed ID: 8633080
Genetics and regulation of two distinct haem-uptake systems, phu and has, in Pseudomonas aeruginosa.
Ochsner UA, Johnson Z, Vasil ML
Microbiology (Reading) 2000 Jan;146 ( Pt 1):185-198
PubMed ID: 10658665