Pseudomonas aeruginosa PAO1, PA4813 (lipC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4813
Name
lipC
Replicon chromosome
Genomic location 5402016 - 5402945 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253500.1
GI 15600006
Affymetrix PA4813_lipC_at
DNASU PaCD00008090
Entrez 880125
GenBank AAG08198.1
INSDC AAG08198.1
NCBI Locus Tag PA4813
protein_id(GenBank) gb|AAG08198.1|AE004894_4|gnl|PseudoCAP|PA4813
TIGR NTL03PA04814
UniParc UPI00000C5E1A
UniProtKB Acc Q9HUZ7
UniProtKB ID Q9HUZ7_PSEAE
UniRef100 UniRef100_Q9HUZ7
UniRef50 UniRef50_B3GVV9
UniRef90 UniRef90_B3GVV9

Product

Feature Type CDS
Coding Frame 1
Product Name
lipase LipC
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -5.14
Kyte-Doolittle Hydrophobicity Value 0.115
Molecular Weight (kDa) 32.3
Isoelectric Point (pI) 5.83

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 2
Unknown (This protein may have multiple localization sites) Class 3
Unknown (This protein may have multiple localization sites) Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 83 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004449 (320 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4813
Search term: lipC
Search term: lipase LipC

Human Homologs

References

LipC, a second lipase of Pseudomonas aeruginosa, is LipB and Xcp dependent and is transcriptionally regulated by pilus biogenesis components.
Martínez A, Ostrovsky P, Nunn DN
Mol Microbiol 1999 Oct;34(2):317-26
PubMed ID: 10564475