Pseudomonas aeruginosa PAO1, PA5003

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5003
Name
Replicon chromosome
Genomic location 5621030 - 5621926 (- strand)
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentNecessary for cationic antimicrobial peptide recognition
CommentRequired for Novispirin G10-tolerant subpopulation formation in flow chamber biofilms

Cross-References

RefSeq NP_253690.1
GI 15600196
Affymetrix PA5003_at
DNASU PaCD00008159
Entrez 881613
GenBank AAG08388.1
INSDC AAG08388.1
NCBI Locus Tag PA5003
protein_id(GenBank) gb|AAG08388.1|AE004913_3|gnl|PseudoCAP|PA5003
TIGR NTL03PA05004
UniParc UPI00000C5EC0
UniProtKB Acc Q9HUG2
UniProtKB ID Q9HUG2_PSEAE
UniRef100 UniRef100_Q9HUG2
UniRef50 UniRef50_G8Q3U3
UniRef90 UniRef90_Z2DKT3

Product

Feature Type CDS
Coding Frame 1
Product Name
Mig-14-like protein
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 8.18
Kyte-Doolittle Hydrophobicity Value -0.361
Molecular Weight (kDa) 33.8
Isoelectric Point (pI) 9.88

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 14 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004611 (517 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5003

Human Homologs

References

A Mig-14-like protein (PA5003) affects antimicrobial peptide recognition in Pseudomonas aeruginosa.
Jochumsen N, Liu Y, Molin S, Folkesson A
Microbiology (Reading) 2011 Sep;157(Pt 9):2647-2657
PubMed ID: 21700666