Pseudomonas aeruginosa PAO1, PA5370

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5370
Name
Replicon chromosome
Genomic location 6045310 - 6046626 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_254057.1
GI 15600563
Affymetrix PA5370_at
Entrez 878571
GenBank AAG08755.1
INSDC AAG08755.1
NCBI Locus Tag PA5370
protein_id(GenBank) gb|AAG08755.1|AE004949_2|gnl|PseudoCAP|PA5370
TIGR NTL03PA05371
UniParc UPI00000C5FC7
UniProtKB Acc Q9HTJ4
UniProtKB ID Q9HTJ4_PSEAE
UniRef100 UniRef100_A0A080VM04
UniRef50 UniRef50_Q48BP4
UniRef90 UniRef90_A0A072ZFB0

Product

Feature Type CDS
Coding Frame 1
Product Name
probable major facilitator superfamily (MFS) transporter
Product Name Confidence: Class 3
Synonyms probable MFS transporter
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 8.30
Kyte-Doolittle Hydrophobicity Value 0.807
Molecular Weight (kDa) 47.0
Isoelectric Point (pI) 9.29

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 2
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 323 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004935 (501 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5370

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Isolation and sequencing of Escherichia coli gene proP reveals unusual structural features of the osmoregulatory proline/betaine transporter, ProP.
Culham DE, Lasby B, Marangoni AG, Milner JL, Steer BA, van Nues RW, Wood JM
J Mol Biol 1993 Jan 5;229(1):268-76
PubMed ID: 8421314