Pseudomonas aeruginosa UCBPP-PA14, PA14_70330 (sphC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14
Locus Tag
PA14_70330
Name
sphC
Replicon chromosome
Genomic location 6271267 - 6272595 (- strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq YP_793801.1
GI 116053474
Entrez 4385090
NCBI Locus Tag PA14_70330

Product

Feature Type CDS
Coding Frame 1
Product Name
SphC
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) -2.50
Kyte-Doolittle Hydrophobicity Value -0.282
Molecular Weight (kDa) 49.4
Isoelectric Point (pI) 6.68

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 128 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004896 (362 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_70330
Search term: sphC
Search term: SphC

Transposon Insertions in UCBPP-PA14

Type MAR2xT7 transposon (wild type background) insertion site
Mutant ID PA14NR: 45093
Genomic Position 6272366
Position in ORF 1100(1329)
Reference 16477005

Transposon Insertions in Orthologs

Type ISlacZ/hah insertion site
Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag PA5327
Mutant ID UWGC: 21363
Genomic Position 5999047
Position in ORF 700(1329)
Reference 14617778
Type Confirmed ISphoA/hah insertion site
Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag PA5327
Mutant ID UWGC: 39702
Genomic Position 5999152
Position in ORF 805(1329)
Reference 14617778

References

Detection of Host-Derived Sphingosine by Pseudomonas aeruginosa Is Important for Survival in the Murine Lung.
Labauve AE, Wargo MJ.
PLoS Pathog. 2014 Jan;10(1):e1003889.
PubMed ID: 24465209