Pseudomonas aeruginosa LESB58, PALES_41991 (tpbB)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa LESB58
GCF_000026645.1|latest |
| Locus Tag |
PALES_41991
|
| Name |
tpbB
|
| Replicon | chromosome |
| Genomic location | 4632845 - 4634152 (+ strand) |
Cross-References
| RefSeq | |
| GI | 218892914 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
diguanylate cyclase TpbB
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -4.88 |
| Kyte-Doolittle Hydrophobicity Value | -0.082 |
| Molecular Weight (kDa) | 47.5 |
| Isoelectric Point (pI) | 6.33 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 7A7E | LIGASE | 08/28/20 | Structure of a delta-N mutant - E232start - of PA1120 (TpbB or YfiN) from Pseudomonas aeruginosa (PAO1) comprising only the GGDEF domain | Pseudomonas aeruginosa PAO1 | 2.8 | X-RAY DIFFRACTION | 100.0 |
| 4IOB | LYASE | 01/07/13 | Crystal structure of the GGDEF domain of PA1120 (YfiN or TpbB) from Pseudomonas aeruginosa at 2.7 Ang. | Pseudomonas aeruginosa | 2.78 | X-RAY DIFFRACTION | 100.0 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 457 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG001080 (443 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PALES_41991
Search term: tpbB
Search term: diguanylate cyclase TpbB
|
Human Homologs
References
|
Connecting quorum sensing, c-di-GMP, pel polysaccharide, and biofilm formation in Pseudomonas aeruginosa through tyrosine phosphatase TpbA (PA3885).
Ueda A, Wood TK
PLoS Pathog 2009 Jun;5(6):e1000483
PubMed ID: 19543378
|