Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA0260
|
Name |
tle3
|
Replicon | chromosome |
Genomic location | 291154 - 293304 (- strand) |
Transposon Mutants | 3 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
Comment | Tle3 is an antibacterial T6SS effector. Toxic when delivered into the periplasm of prey bacteria. Tle3 is dependent on the H2-T6SS machinery , Tla3 and VgrG2b for its secretion. Tli3 neutralizes its antibacterial activity. |
RefSeq | NP_248951.1 |
GI | 15595457 |
Affymetrix | PA0260_at |
Entrez | 879499 |
GenBank | AAG03649.1 |
INSDC | AAG03649.1 |
NCBI Locus Tag | PA0260 |
protein_id(GenBank) | gb|AAG03649.1|AE004464_2|gnl|PseudoCAP|PA0260 |
TIGR | NTL03PA00261 |
UniParc | UPI00000C4FC9 |
UniProtKB Acc | Q9I6M9 |
UniProtKB ID | Q9I6M9_PSEAE |
UniRef100 | UniRef100_Q9I6M9 |
UniRef50 | UniRef50_Q9I6M9 |
UniRef90 | UniRef90_Q9I6M9 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
Type 6 lipase effector, Tle3
|
Synonyms |
Tle3 |
Evidence for Translation | |
Charge (pH 7) | -0.33 |
Kyte-Doolittle Hydrophobicity Value | -0.370 |
Molecular Weight (kDa) | 78.2 |
Isoelectric Point (pI) | 6.96 |
Individual Mappings | |
Additional evidence for subcellular localization |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 17 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG000258 (272 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA0260
Search term: tle3
Search term: Type 6 lipase effector, Tle3
|
Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors.
Russell AB, LeRoux M, Hathazi K, Agnello DM, Ishikawa T, Wiggins PA, Wai SN, Mougous JD
Nature 2013 Apr 25;496(7446):508-12
PubMed ID: 23552891
|
Internalization of Pseudomonas aeruginosa Strain PAO1 into Epithelial Cells Is Promoted by Interaction of a T6SS Effector with the Microtubule Network.
Sana TG, Baumann C, Merdes A, Soscia C, Rattei T, Hachani A, Jones C, Bennett KL, Filloux A, Superti-Furga G, Voulhoux R, Bleves S
mBio 2015 Jun 2;6(3):e00712
PubMed ID: 26037124
|
A Type VI Secretion System Trans-Kingdom Effector Is Required for the Delivery of a Novel Antibacterial Toxin in Pseudomonas aeruginosa.
Berni B, Soscia C, Djermoun S, Ize B, Bleves S
Front Microbiol 2019;10:1218
PubMed ID: 31231326
|