Pseudomonas aeruginosa PAO1, PA0305 (hacB)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Molecular Function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	21372094	Reviewed by curator
Molecular Function	GO:0016787	hydrolase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:PF01804	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Biological Process	GO:0017000	antibiotic biosynthetic process	ISM Inferred from Sequence Model Term mapped from: InterPro:PF01804	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	ISM Inferred from Sequence Model Term mapped from: InterPro:PIRSF001227	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Carbon compound catabolism Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
KEGG	pae01130	Biosynthesis of antibiotics	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
PIRSF	PIRSF001227	Pen_acylase	IPR014395	Penicillin/GL-7-ACA/AHL acylase	1	794	0.0
Gene3D	G3DSA:1.10.1400.10	-	IPR043147	Penicillin amidase type, A-knob	542	678	0.0
Pfam	PF01804	Penicillin amidase	IPR002692	Penicillin/GL-7-ACA/AHL/aculeacin-A acylase	42	782	0.0
SUPERFAMILY	SSF56235	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	IPR029055	Nucleophile aminohydrolases, N-terminal	39	794	0.0
Gene3D	G3DSA:3.60.20.10	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1	IPR029055	Nucleophile aminohydrolases, N-terminal	248	773	0.0
PANTHER	PTHR34218	PEPTIDASE S45 PENICILLIN AMIDASE	IPR002692	Penicillin/GL-7-ACA/AHL/aculeacin-A acylase	2	793	0.0
Gene3D	G3DSA:2.30.120.10	-	IPR043146	Penicillin amidase type, N-terminal domain, B-knob	320	391	0.0
Gene3D	G3DSA:1.10.439.10	Penicillin Amidohydrolase, domain 1	IPR023343	Penicillin amidase type, domain 1	13	176	1.5E-52
CDD	cd03747	Ntn_PGA_like	-	-	248	538	1.26834E-108

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.