Pseudomonas aeruginosa PAO1, PA0350 (folA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0046654 tetrahydrofolate biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00186
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004146 dihydrofolate reductase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00186
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006545 glycine biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000194
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0050661 NADP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000194
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Biosynthesis of cofactors, prosthetic groups and carriers Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCyc ALL-CHORISMATE-PWY superpathway of chorismate metabolism 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc 1CMET2-PWY N<sup>10</sup>-formyl-tetrahydrofolate biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae00670 One carbon pool by folate 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc PWY-6612 superpathway of tetrahydrofolate biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc PWY-6614 tetrahydrofolate biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCAP Folate biosynthesis ECO:0000037
not_recorded
KEGG pae00790 Folate biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP One carbon pool by folate ECO:0000037
not_recorded
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
PRINTS PR00070 Dihydrofolate reductase signature - - 100 114 6.8E-16
PRINTS PR00070 Dihydrofolate reductase signature - - 16 26 6.8E-16
PANTHER PTHR48069 DIHYDROFOLATE REDUCTASE IPR012259 Dihydrofolate reductase 5 166 4.1E-37
FunFam G3DSA:3.40.430.10:FF:000001 Dihydrofolate reductase - - 3 168 3.3E-61
PIRSF PIRSF000194 DHFR IPR012259 Dihydrofolate reductase 1 168 1.6E-58
Pfam PF00186 Dihydrofolate reductase IPR001796 Dihydrofolate reductase domain 5 167 1.2E-54
PRINTS PR00070 Dihydrofolate reductase signature - - 43 54 6.8E-16
CDD cd00209 DHFR IPR001796 Dihydrofolate reductase domain 5 151 1.36152E-69
Gene3D G3DSA:3.40.430.10 Dihydrofolate Reductase, subunit A IPR024072 Dihydrofolate reductase-like domain superfamily 4 168 6.9E-56
PRINTS PR00070 Dihydrofolate reductase signature - - 30 38 6.8E-16
SUPERFAMILY SSF53597 Dihydrofolate reductase-like IPR024072 Dihydrofolate reductase-like domain superfamily 4 168 2.11E-55

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.