Pseudomonas aeruginosa PAO1, PA3676 (mexK)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0046677 response to antibiotic
IMP
Inferred from Mutant Phenotype 		ECO:0000016
loss-of-function mutant phenotype evidence		 12193619 Reviewed by curator
Molecular Function GO:0022857 transmembrane transporter activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00702
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0055085 transmembrane transport
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00702
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0016020 membrane
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00702
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Transport of small molecules Other PAO1 genes in this class
Antibiotic resistance and susceptibility Other PAO1 genes in this class
Membrane proteins Other PAO1 genes in this class

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
SUPERFAMILY SSF82693 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains - - 566 659 7.59E-5
Gene3D G3DSA:3.30.70.1440 Multidrug efflux transporter AcrB pore domain - - 664 865 0.0
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 439 462 3.0E-23
SUPERFAMILY SSF82866 Multidrug efflux transporter AcrB transmembrane domain - - 796 1020 3.79E-47
Pfam PF00873 AcrB/AcrD/AcrF family IPR001036 Acriflavin resistance protein 7 1013 0.0
SUPERFAMILY SSF82693 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains - - 140 325 3.14E-17
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 464 487 3.0E-23
SUPERFAMILY SSF82866 Multidrug efflux transporter AcrB transmembrane domain - - 301 490 2.22E-36
Gene3D G3DSA:3.30.70.1430 Multidrug efflux transporter AcrB pore domain - - 565 663 0.0
Gene3D G3DSA:3.30.2090.10 Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains 715 803 0.0
Gene3D G3DSA:3.30.70.1430 Multidrug efflux transporter AcrB pore domain - - 42 811 0.0
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 358 379 3.0E-23
SUPERFAMILY SSF82714 Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains 714 800 2.75E-14
Gene3D G3DSA:3.30.70.1320 Multidrug efflux transporter AcrB pore domain like - - 138 327 0.0
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 40 58 3.0E-23
Gene3D G3DSA:1.20.1640.10 Multidrug efflux transporter AcrB transmembrane domain - - 14 501 0.0
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 547 564 3.0E-23
Gene3D G3DSA:1.20.1640.10 Multidrug efflux transporter AcrB transmembrane domain - - 502 1012 0.0
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 386 410 3.0E-23
SUPERFAMILY SSF82714 Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains 187 267 1.7E-11
Gene3D G3DSA:3.30.2090.10 Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains 182 274 0.0
SUPERFAMILY SSF82693 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains - - 42 136 1.83E-19
PANTHER PTHR32063 - IPR001036 Acriflavin resistance protein 1 1022 0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.