Pseudomonas aeruginosa PAO1, PA3814 (iscS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006790 sulfur compound metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0051188 obsolete cofactor biosynthetic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Molecular Function GO:0005515 protein binding
Interaction partner: PseudoCAP:PA1006
IPI
Inferred from Physical Interaction 		ECO:0000024
protein binding evidence		 23409003 Reviewed by curator
Biological Process GO:0006534 cysteine metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0006520 cellular amino acid metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0044571 [2Fe-2S] cluster assembly
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00331
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0031071 cysteine desulfurase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00331
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0030170 pyridoxal phosphate binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_00331
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Biosynthesis of cofactors, prosthetic groups and carriers Other PAO1 genes in this class
Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae00730 Thiamine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Sulfur metabolism ECO:0000037
not_recorded
KEGG pae04122 Sulfur relay system 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Cysteine metabolism ECO:0000037
not_recorded

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
FunFam G3DSA:3.90.1150.10:FF:000002 Cysteine desulfurase IscS - - 257 368 4.5E-50
PIRSF PIRSF005572 NifS IPR016454 Cysteine desulfurase 2 384 0.0
NCBIfam TIGR02006 JCVI: IscS subfamily cysteine desulfurase IPR010240 Cysteine desulfurase IscS 1 404 0.0
FunFam G3DSA:3.40.640.10:FF:000003 Cysteine desulfurase IscS - - 16 263 1.0E-130
Gene3D G3DSA:3.40.640.10 - IPR015421 Pyridoxal phosphate-dependent transferase, major domain 16 263 0.0
Gene3D G3DSA:3.90.1150.10 Aspartate Aminotransferase, domain 1 IPR015422 Pyridoxal phosphate-dependent transferase, small domain 5 368 0.0
Pfam PF00266 Aminotransferase class-V IPR000192 Aminotransferase class V domain 5 368 4.2E-85
Hamap MF_00331 Cysteine desulfurase IscS [iscS]. IPR010240 Cysteine desulfurase IscS 1 395 53.60817
SUPERFAMILY SSF53383 PLP-dependent transferases IPR015424 Pyridoxal phosphate-dependent transferase 5 391 6.12E-111
PANTHER PTHR11601 CYSTEINE DESULFURYLASE FAMILY MEMBER - - 3 384 0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.