Pseudomonas aeruginosa PAO1, PA4044 (dxs)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0051188 obsolete cofactor biosynthetic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Molecular Function GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00204
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF52922
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0016114 terpenoid biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00204
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Biosynthesis of cofactors, prosthetic groups and carriers Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCyc PWY-6892 thiazole biosynthesis I (E. coli) 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc THISYN-PWY superpathway of thiamin diphosphate biosynthesis I 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00900 Terpenoid backbone biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc NONMEVIPP-PWY methylerythritol phosphate pathway I 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc PYRIDOXSYN-PWY pyridoxal 5'-phosphate biosynthesis I 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae00730 Thiamine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
PANTHER PTHR43322 1-D-DEOXYXYLULOSE 5-PHOSPHATE SYNTHASE-RELATED IPR005477 Deoxyxylulose-5-phosphate synthase 9 626 0.0
Gene3D G3DSA:3.40.50.970 - - - 323 491 4.2E-54
SUPERFAMILY SSF52518 Thiamin diphosphate-binding fold (THDP-binding) IPR029061 Thiamin diphosphate-binding fold 15 386 7.41E-77
Pfam PF13292 1-deoxy-D-xylulose-5-phosphate synthase IPR005477 Deoxyxylulose-5-phosphate synthase 18 289 2.3E-121
Gene3D G3DSA:3.40.50.920 - IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II 500 625 6.4E-37
SMART SM00861 Transket_pyr_3 IPR005475 Transketolase-like, pyrimidine-binding domain 324 488 8.8E-63
SUPERFAMILY SSF52922 TK C-terminal domain-like IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II 496 625 2.62E-33
Gene3D G3DSA:3.40.50.970 - - - 11 298 8.3E-83
FunFam G3DSA:3.40.50.920:FF:000002 1-deoxy-D-xylulose-5-phosphate synthase - - 500 625 6.5E-44
Pfam PF02780 Transketolase, C-terminal domain IPR033248 Transketolase, C-terminal domain 500 616 4.1E-27
Pfam PF02779 Transketolase, pyrimidine binding domain IPR005475 Transketolase-like, pyrimidine-binding domain 325 485 1.9E-36
NCBIfam TIGR00204 JCVI: 1-deoxy-D-xylulose-5-phosphate synthase IPR005477 Deoxyxylulose-5-phosphate synthase 22 624 0.0
CDD cd02007 TPP_DXS IPR005477 Deoxyxylulose-5-phosphate synthase 54 295 5.54859E-123
FunFam G3DSA:3.40.50.970:FF:000005 1-deoxy-D-xylulose-5-phosphate synthase - - 323 490 1.3E-79
SUPERFAMILY SSF52518 Thiamin diphosphate-binding fold (THDP-binding) IPR029061 Thiamin diphosphate-binding fold 321 508 1.23E-56
CDD cd07033 TPP_PYR_DXS_TK_like - - 329 482 4.33512E-69
Hamap MF_00315 1-deoxy-D-xylulose-5-phosphate synthase [dxs]. IPR005477 Deoxyxylulose-5-phosphate synthase 17 625 46.223408

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.