Pseudomonas aeruginosa UCBPP-PA14, PA14_04480 (thyA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0016741 transferase activity, transferring one-carbon groups
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PTHR11548
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006231 dTMP biosynthetic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR03284
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004799 thymidylate synthase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR03284
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Nucleotide biosynthesis and metabolism Other UCBPP-PA14 genes in this class
Biosynthesis of cofactors, prosthetic groups and carriers Other UCBPP-PA14 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pau01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00670 One carbon pool by folate 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00240 Pyrimidine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
PRINTS PR00108 Thymidylate synthase family signature IPR000398 Thymidylate synthase 42 63 9.9E-48
NCBIfam TIGR03284 JCVI: thymidylate synthase IPR000398 Thymidylate synthase 2 85 1.4E-40
Hamap MF_00008 Thymidylate synthase [thyA]. IPR000398 Thymidylate synthase 1 264 41.267605
CDD cd00351 TS_Pyrimidine_HMase IPR023451 Thymidylate synthase/dCMP hydroxymethylase domain 3 216 2.09763E-126
PRINTS PR00108 Thymidylate synthase family signature IPR000398 Thymidylate synthase 115 134 9.9E-48
Gene3D G3DSA:3.30.572.10 Thymidylate synthase/dCMP hydroxymethylase domain IPR036926 Thymidylate synthase/dCMP hydroxymethylase superfamily 1 264 0.0
PRINTS PR00108 Thymidylate synthase family signature IPR000398 Thymidylate synthase 197 214 9.9E-48
PANTHER PTHR11548 THYMIDYLATE SYNTHASE 1 IPR045097 Thymidylate synthase/dCMP hydroxymethylase 2 264 1.9E-113
PRINTS PR00108 Thymidylate synthase family signature IPR000398 Thymidylate synthase 159 185 9.9E-48
NCBIfam TIGR03284 JCVI: thymidylate synthase IPR000398 Thymidylate synthase 84 264 5.3E-96
FunFam G3DSA:3.30.572.10:FF:000001 Thymidylate synthase - - 1 264 0.0
Pfam PF00303 Thymidylate synthase IPR023451 Thymidylate synthase/dCMP hydroxymethylase domain 2 264 1.0E-126
SUPERFAMILY SSF55831 Thymidylate synthase/dCMP hydroxymethylase IPR036926 Thymidylate synthase/dCMP hydroxymethylase superfamily 1 264 0.0
PRINTS PR00108 Thymidylate synthase family signature IPR000398 Thymidylate synthase 141 156 9.9E-48

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.